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Home / Proteins & Peptide

IL-12, Mouse

SKU : BHP18500366

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iXCells Biotechnologies

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Mfr.No.	IX03211, IX03211-1, IX03211-10, IX03211-50
Description	Interleukin-12 (IL-12), also known as NKSF, TCMF, CLMF and TSF, is a heterodimeric cytokine composed of p35 and p40 subunits. It is produced by monocytes, macrophages, B cells and dendritic cells in response to bacterial lipopolysaccharides and intracellular pathogens. IL-12 signals throughtheIL-12 receptor complex, which is comprised of IL-12 Rbeta1 and IL-12 Rbeta2. IL-12 induces the proliferation and activation of hematopoietic stem cells, natural killer cells and T- cells. It is indispensible during the development of Th1 cells, leading to the production of IFN-gamma and IL-2.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	27-29 kDa (p35) and 45-50 kDa (p40), observed by reducing SDS-PAGE.
Source	CHO
Host	Mouse
Accession Number	P43431
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 0.15 ng/ml, measured in a cell proliferation assay using 2D6 cells.

Synonyms	NKSF, TCMF, CLMF, TSF
Sequence	p35 Subunit: RVIPVSGPAR CLSQSRNLLK TTDDMVKTAR EKLKHYSCTA EDIDHEDITR DQTSTLKTCL?PLELHKNESC LATRETSSTT RGSCLPPQKT SLMMTLCLGS IYEDLKMYQT EFQAINAALQ?NHNHQQIILD KGMLVAIDEL MQSLNHNGET LRQKPPVGEA DPYRVKMKLC ILLHAFSTRV?VTINRVMGYL SSAp40 Subunit:MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF?LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL?VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE?TLPIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP?HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS?CSKWACVPCR VRS

Purity	95% as analyzed by SDS-PAGE.
Storage	Lyophilized recombinant murineInterleukin-12 (IL-12), remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, murine Interleukin-12 (IL-12), His should be stable up to 1 week at 4°C or up to 2 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500366-1	IX03211-1	1mg	$3993		Add to Cart
BHP18500366-2	IX03211-10	10ug	$107		Add to Cart
BHP18500366-3	IX03211-50	50ug	$563		Add to Cart

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