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Home / Primary Antibodies / IHC Antibodies

ZFHX3 Antibody

SKU : BHA10557938

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA176078
Alternative Names	Zinc finger homeodomain protein 3; ZFH-3; Alpha-fetoprotein enhancer-binding protein; AT motif-binding factor; AT-binding transcription factor 1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer.Miura Y., J. Biol. Chem. 270:26840-26848(1995).Morinaga T., Mol. Cell. Biol. 11:6041-6049(1991).Martin J., Nature 432:988-994(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human ZFHX3.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer. Miura Y., J. Biol. Chem. 270:26840-26848(1995). Morinaga T., Mol. Cell. Biol. 11:6041-6049(1991). Martin J., Nature 432:988-994(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ZFHX3 protein.
Subcellular Location	Nucleus, Cytoplasm

Uniprot	Q15911
Gene Id	463
Database Links	HGNC:777 OMIM:104155 KEGG:hsa:463 STRING:9606.ENSP00000268489 UniGene:Hs.598297
Function	Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3
Pathway	Signaling pathways regulating pluripotency of stem cells
Tissue Specificity	Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level). Expression is higher in ER-positive breast tumors than ER-negative breast tumors (at protein level).
Weight	306,664 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:50-1:100

Tested Application

ELISA,IHC;IHC:1:50-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557938	CSB-PA176078	100ul	$297		Add to Cart

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