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Home / Primary Antibodies / IHC Antibodies

XPA Antibody

SKU : BHA10559791

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA238469
Alternative Names	DNA-repair protein complementing XP-A cells; XPAC; Xeroderma pigmentosum group A complementing protein;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.Gary W. Daughdrill, Nucleic Acids Res., Jul 2003; 31: 4176 - 4183. Esther M. Hoogervorst, Carcinogenesis, Mar 2003; 24: 613 - 619. Karen M. Vasquez, PNAS, Apr 2002; 99: 5848.
Host	Rabbit
Immunogen	Synthesized peptide derived from Internal of Human XPA.
Involvement In Disease	Xeroderma pigmentosum complementation group A (XP-A)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Gary W. Daughdrill, Nucleic Acids Res., Jul 2003; 31: 4176 - 4183. Esther M. Hoogervorst, Carcinogenesis, Mar 2003; 24: 613 - 619. Karen M. Vasquez, PNAS, Apr 2002; 99: 5848.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total XPA protein.
Subcellular Location	Nucleus

Uniprot	P23025
Database Links	HGNC:12814 OMIM:278700 KEGG:hsa:7507 STRING:9606.ENSP00000364270 UniGene:Hs.654364
Function	Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Pathway	DNA repair pathway
Protein Families	XPA family
Tissue Specificity	Expressed in various cell lines and in skin fibroblasts.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559791	CSB-PA238469	100ul	$297		Add to Cart

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