USP6 N-terminal-like protein; Related to the N-terminus of tre; RN-tre; USP6NL; KIAA0019
Antigen
USP6NL
Categories
Primary Antibodies
Clonality
polyclonal
Description
Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.Wong W.T., Oncogene 12:2563-2571(1996).Nomura N., DNA Res. 1:27-35(1994).Lanzetti L., Nature 408:374-377(2000)
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human USP6NL.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.
Wong W.T., Oncogene 12:2563-2571(1996). Nomura N., DNA Res. 1:27-35(1994). Lanzetti L., Nature 408:374-377(2000)
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total USP6NL protein.
Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.
Tissue Specificity
Widely expressed.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.