C20orf1; C20orf2; DIL-2; DIL2; Differentially expressed in lung cells 2
Antigen
TPX2
Categories
Primary Antibodies
Clonality
polyclonal
Description
Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.Manda R., Genomics 61:5-14(1999).Zhang Y., Cytogenet. Cell Genet. 84:182-183(1999).Wang Y., J. Immunol. 169:1102-1109(2002).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human DIL-2.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.
Manda R., Genomics 61:5-14(1999). Zhang Y., Cytogenet. Cell Genet. 84:182-183(1999). Wang Y., J. Immunol. 169:1102-1109(2002).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total DIL-2 protein.
Subcellular Location
Nucleus, Cytoplasm, cytoskeleton, spindle, Cytoplasm, cytoskeleton, spindle pole
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules
Protein Families
TPX2 family
Tissue Specificity
Expressed in lung carcinoma cell lines but not in normal lung tissues.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.