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Home / Primary Antibodies / IHC Antibodies

TOP2A Antibody

SKU : BHA10559809

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA105332
Alternative Names	DNA topoisomerase 2-alpha; EC 5.99.1.3; DNA topoisomerase II; alpha isozyme; TOP2A
Categories	Primary Antibodies
Clonality	polyclonal
Description	Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.Tsai-Pflugfelder M., Proc. Natl. Acad. Sci. U.S.A. 85:7177-7181(1988).Wasserman R.A., Cancer Res. 53:3591-3596(1993).Lang A.J., Gene 221:255-266(1998).
Host	Rabbit
Immunogen	Synthesized peptide derived from N-terminal of Human TOP2A.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. Tsai-Pflugfelder M., Proc. Natl. Acad. Sci. U.S.A. 85:7177-7181(1988). Wasserman R.A., Cancer Res. 53:3591-3596(1993). Lang A.J., Gene 221:255-266(1998).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TOP2A protein.
Subcellular Location	Cytoplasm, Nucleus, nucleoplasm

Uniprot	P11388
Database Links	HGNC:11989 OMIM:126430 KEGG:hsa:7153 STRING:9606.ENSP00000411532 UniGene:Hs.156346
Function	Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).
Protein Families	Type II topoisomerase family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559809	CSB-PA105332	100ul	$297		Add to Cart

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