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Home / Primary Antibodies / IHC Antibodies

TNFAIP8 Antibody

SKU : BHA10559803

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA993947
Alternative Names	Tumor necrosis factor; alpha-induced protein 8; Head and neck tumor and metastasis-related protein; TNF-induced protein GG2-1; SCC-S2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.Horrevoets A.J.G., Blood 93:3418-3431(1999).Kumar D., J. Biol. Chem. 275:2973-2978(2000).You Z., J. Biol. Chem. 276:26398-26404(2001).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human TFIP8.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. Horrevoets A.J.G., Blood 93:3418-3431(1999). Kumar D., J. Biol. Chem. 275:2973-2978(2000). You Z., J. Biol. Chem. 276:26398-26404(2001).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TFIP8 protein.
Subcellular Location	Cytoplasm

Uniprot	O95379
Database Links	HGNC:17260 OMIM:612111 KEGG:hsa:25816 STRING:9606.ENSP00000421848 UniGene:Hs.618488
Function	Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Protein Families	TNFAIP8 family
Tissue Specificity	Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, l

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559803	CSB-PA993947	100ul	$297		Add to Cart

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