Protein name Tumor necrosis factor [Precursor]; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin
Antigen
TNF
Categories
Primary Antibodies
Clonality
polyclonal
Description
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.Neville M.J., J. Immunol. 162:4745-4754(1999).Xie T., Genome Res. 13:2621-2636(2003).Kim Y.J., Hum. Mol. Genet. 12:2541-2546(2003).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human TNFA.
Involvement In Disease
Psoriatic arthritis (PSORAS)
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
Neville M.J., J. Immunol. 162:4745-4754(1999). Xie T., Genome Res. 13:2621-2636(2003). Kim Y.J., Hum. Mol. Genet. 12:2541-2546(2003).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total TNFA protein.
Subcellular Location
Cell membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Tumor necrosis factor, membrane form: Membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Tumor necrosis factor, soluble form: Secreted, SUBCELLULAR LOCATION: C-domain 1: Secreted, SUBCELLULAR LOCATION: C-domain 2: Secreted
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective