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Home / Primary Antibodies / IHC Antibodies

TLR5 Antibody

SKU : BHA10557260

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA023604KA01HU
Alternative Names	TLR5; FLJ10052; MGC126430; MGC126431; SLEB1; TIL3
Categories	Primary Antibodies
Description	This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
Hgnc	11851
Host	Rabbit
Immunogen	Recombinant protein of human TLR5
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Involvement In Disease	Systemic lupus erythematosus 1 (SLEB1)
Isotype	IgG
Mgi	1858171
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Membrane, Single-pass type I membrane protein

Rgd	631351
Uniprot	O60602
Database Links	HGNC:11851 OMIM:109100 KEGG:hsa:7100 STRING:9606.ENSP00000340089 UniGene:Hs.604542
Function	Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Pathway	Toll-like receptor signaling pathway
Protein Families	Toll-like receptor family
Tissue Specificity	Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557260	CSB-PA023604KA01HU	100μl	$387.33		Add to Cart

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