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Home / Primary Antibodies / IHC Antibodies

TK1 (Ab-13) Antibody

SKU : BHA10559688

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA999799
Alternative Names	EC 2.7.1.21; KITH; TK-1; TK1; Thymidine kinase
Categories	Primary Antibodies
Clonality	polyclonal
Description	Thymidine kinases play a critical role in generating the DNA synthetic precursor deoxythymidine triphosphate (dTTP) by catalyzing the phosphotransfer of phosphate from ATP to deoxythymidine (dT) and thymidine (T) in the cell.TK1 expression and activity is regulated in a cell cycle-dependent manner, accumulating during G1-phase to peak levels in S-phase before being degraded prior to cell division. Stability, but not activity, may be regulated via phosphorylation of TK1 at Ser13 by Cdc2 and/or Cdk2, but the precise mode of regulation remains elusive. These observations indicate that TK1 might be a useful marker of cell proliferation; however, recent studies have shown that TK1 plays a more significant role in the DNA damage response.N Singh, Mol. Cell. Biol., May 1991; 11: 2362 - 2374. Bin Tian, Am. J. Pathol., Aug 2003; 163: 789. Ren篓 Gerolami, Cancer Res., Feb 2000; 60: 993 - 1001. Catia Traversari, Blood, Jun 2007; 109: 4708 - 4715
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human TK around the phosphorylation site of serine 13 (P-G-S(p)-P-S).
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Thymidine kinases play a critical role in generating the DNA synthetic precursor deoxythymidine triphosphate (dTTP) by catalyzing the phosphotransfer of phosphate from ATP to deoxythymidine (dT) and thymidine (T) in the cell.TK1 expression and activity is regulated in a cell cycle-dependent manner, accumulating during G1-phase to peak levels in S-phase before being degraded prior to cell division. Stability, but not activity, may be regulated via phosphorylation of TK1 at Ser13 by Cdc2 and/or Cdk2, but the precise mode of regulation remains elusive. These observations indicate that TK1 might be a useful marker of cell proliferation; however, recent studies have shown that TK1 plays a more significant role in the DNA damage response. N Singh, Mol. Cell. Biol., May 1991; 11: 2362 - 2374. Bin Tian, Am. J. Pathol., Aug 2003; 163: 789. RenGerolami, Cancer Res., Feb 2000; 60: 993 - 1001. Catia Traversari, Blood, Jun 2007; 109: 4708 - 4715
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TK protein
Subcellular Location	Cytoplasm

Uniprot	P04183
Database Links	HGNC:11830 OMIM:188300 KEGG:hsa:7083 STRING:9606.ENSP00000301634 UniGene:Hs.515122
Protein Families	Thymidine kinase family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559688	CSB-PA999799	100ul	$297		Add to Cart

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