TIMP metallopeptidase inhibitor 4; tissue inhibitor of metalloproteinase 4; Metalloproteinase inhibitor 4;
Categories
Primary Antibodies
Clonality
polyclonal
Description
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.Jennifer Adjodha, AACR Meeting Abstracts, Apr 2005; 2005: 699. Kiyoshi Asada, AACR Meeting Abstracts, Apr 2005; 2005: 202. Elaine K Green, J. Med. Genet., Aug 2000; 37: 581. Jennifer Adjodha, AACR Meeting Abstracts, Apr 2006; 2006: 1028.
Host
Rabbit
Immunogen
Synthesized peptide derived from C-terminal of Human TIMP4.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
Jennifer Adjodha, AACR Meeting Abstracts, Apr 2005; 2005: 699. Kiyoshi Asada, AACR Meeting Abstracts, Apr 2005; 2005: 202. Elaine K Green, J. Med. Genet., Aug 2000; 37: 581. Jennifer Adjodha, AACR Meeting Abstracts, Apr 2006; 2006: 1028.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total TIMP4 protein.
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
Protein Families
Protease inhibitor I35 (TIMP) family
Tissue Specificity
Abundant in heart and present at low levels in many other tissues.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.