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Home / Primary Antibodies / IHC Antibodies

SUMO1 Antibody

SKU : BHA10559784

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA042567
Alternative Names	PIC1; SENTRIN; SMT3C; SMT3H3; UBL1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.Margarita Vigodner, Am J Physiol Endocrinol Metab, May 2006; 290: E1022 - E1033. Adrian Minty, J. Biol. Chem., Nov 2000; 275: 36316. Deborah A. Sampson, J. Biol. Chem., Jun 2001; 276: 21664 - 21669. Hidehisa Takahashi, J. Biol. Chem., Feb 2005; 280: 56
Host	Rabbit
Immunogen	Synthesized peptide derived from N-terminal of Human SUMO-1.
Involvement In Disease	Non-syndromic orofacial cleft 10 (OFC10)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Margarita Vigodner, Am J Physiol Endocrinol Metab, May 2006; 290: E1022 - E1033. Adrian Minty, J. Biol. Chem., Nov 2000; 275: 36316. Deborah A. Sampson, J. Biol. Chem., Jun 2001; 276: 21664 - 21669. Hidehisa Takahashi, J. Biol. Chem., Feb 2005; 280: 56
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total SUMO-1 protein.
Subcellular Location	Nucleus membrane, Nucleus speckle, Cytoplasm, Nucleus, PML body, Cell membrane, Nucleus

Uniprot	P63165
Database Links	HGNC:12502 OMIM:601912 KEGG:hsa:7341 STRING:9606.ENSP00000376076 UniGene:Hs.81424
Function	Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1
Protein Families	Ubiquitin family, SUMO subfamily

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559784	CSB-PA042567	100ul	$297		Add to Cart

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