Signal transducer and activator of transcription 5B;
Antigen
STAT5b
Categories
Primary Antibodies
Clonality
polyclonal
Description
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.Zsuzsanna S. Nagy, J. Leukoc. Biol., Oct 2002; 72: 819.Stanislaw M. Stepkowski, Blood, Jan 2002; 99: 680 - 689.Salvador Aznar Benitah, Mol. Biol. Cell, Jan 2003; 14: 40.
Host
Rabbit
Immunogen
Synthesized non-phosphopeptide derived from Human STAT5B around the phosphorylation site of serine 731(A-P-S-P-A).
Involvement In Disease
Growth hormone insensitivity with immunodeficiency (GHII)
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.
Zsuzsanna S. Nagy, J. Leukoc. Biol., Oct 2002; 72: 819. Stanislaw M. Stepkowski, Blood, Jan 2002; 99: 680 - 689. Salvador Aznar Benitah, Mol. Biol. Cell, Jan 2003; 14: 40.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total STAT5B protein.