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Home / Primary Antibodies / IHC Antibodies

STAT3 (Ab-727) Antibody

SKU : BHA10558954

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA088158
Alternative Names	Acute-phase response factor
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Heim M H, (1999) J Recept Signal Transduct Res. 19: 75-120.Takeda K, et al. (1997) Proc Natl Acad Sci USA. 94: 3801-3804.Catlett-Falcone R, et al. (1999) Immunity. 10: 105-115.Garcia R, et al. (1998) J Biomed Sci. 5: 79-85.Bromberg J F, et al. (1999) Cell. 98: 295-303.
Host	Rabbit
Immunogen	Peptide sequence around aa. 725~729 (P-M-S-P-R) derived from Human STAT3.
Involvement In Disease	Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant (AD-HIES); Autoimmune disease, multisystem, infantile-onset, 1 (ADMIO1)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Heim M H, (1999) J Recept Signal Transduct Res. 19: 75-120. Takeda K, et al. (1997) Proc Natl Acad Sci USA. 94: 3801-3804. Catlett-Falcone R, et al. (1999) Immunity. 10: 105-115. Garcia R, et al. (1998) J Biomed Sci. 5: 79-85. Bromberg J F, et al. (1999) Cell. 98: 295-303.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total STAT3 protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P40763
Gene Id	6774
Database Links	HGNC:11364 OMIM:102582 KEGG:hsa:6774 STRING:9606.ENSP00000264657 UniGene:Hs.463059
Function	Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors
Pathway	Chemokine signaling pathway HIF-1 signaling pathway Jak-STAT signaling pathway Necroptosis Signaling pathways regulating pluripotency of stem cells Th17 cell differentiation Adipocytokine signaling pathway AGE-RAGE signaling pathway in diabetic complications FoxO signaling pathway
Protein Families	Transcription factor STAT family
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Weight	22kDa

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558954	CSB-PA088158	100ul	$297		Add to Cart

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