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Home / Primary Antibodies / IHC Antibodies

SIRT2 Antibody

SKU : BHA10557116

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA021340KA01HU
Alternative Names	SIRT2;SIR2;SIR2L;SIR2L2
Categories	Primary Antibodies
Description	Sirtuins are members of the NAD-dependent histone deacetylase family of proteins that participate in a variety of cellular functions, including histone deacetylation, gene silencing, chromosomal stability, and aging. SIRT2, a human homolog of the yeast SIR2 (silent information regulator-2), functions as transcriptional silencing mediator at mating-type loci, telomeres and ribosomal gene clusters. SIRT2 expression increases dramatically during mitosis and is multiply phosphorylated at the G(2)/M transition of the cell cycle. SIRT2 is part of a phosphorylation cascade where it is phosphorylated late in G(2), during M, and into the period of cytokinesis. Inhibition of SIRT2 is reported to rescue alpha-synuclein toxicity and modify inclusion morphology in a cellular model of Parkinsons disease.
Hgnc	10886
Host	Rabbit
Immunogen	C term -peptide of Human SIRT2
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Isotype	IgG
Mgi	1927664
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Sirtuins are members of the NAD-dependent histone deacetylase family of proteins that participate in a variety of cellular functions, including histone deacetylation, gene silencing, chromosomal stability, and aging. SIRT2, a human homolog of the yeast SIR2 (silent information regulator-2), functions as transcriptional silencing mediator at mating-type loci, telomeres and ribosomal gene clusters. SIRT2 expression increases dramatically during mitosis and is multiply phosphorylated at the G(2)/M transition of the cell cycle. SIRT2 is part of a phosphorylation cascade where it is phosphorylated late in G(2), during M, and into the period of cytokinesis. Inhibition of SIRT2 is reported to rescue alpha-synuclein toxicity and modify inclusion morphology in a cellular model of Parkinsons disease.
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Nucleus, Cytoplasm, perinuclear region, Cytoplasm, Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, Cytoplasm, cytoskeleton, spindle, Midbody, Chromosome, Perikaryon, Cell projection, Cell projection, growth cone, Myelin membrane, Note=Deacetylates FOXO3 in the cytoplasm, Colocalizes with PLP1 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat, Colocalizes with CDK5R1 in the perikaryon, neurites and growth cone of hippocampal neurons, Colocalizes with alpha-tubulin in neuronal growth cone, Localizes in the cytoplasm and nucleus of germinal vesicle (GV) stage oocytes, Colocalizes with alpha-tubulin on the meiotic spindle as the oocytes enter into metaphase, and also during meiotic anaphase and telophase, especially with the midbody, Colocalizes with PARD3 in internodal region of axons, Colocalizes with acetylated alpha-tubulin in cell projection processes during primary oligodendrocyte precursor (OLP) differentiation (By similarity), Localizes in the cytoplasm during most of the cell cycle except in the G2/M transition and during mitosis, where it is localized in association with chromatin and induces deacetylation of histone at 'Lys-16' (H4K16ac), Colocalizes with KMT5A at mitotic foci, Colocalizes with CDK1 at centrosome during prophase and splindle fibers during metaphase, Colocalizes with Aurora kinase AURKA at centrosome during early prophase and in the centrioles and growing mitotic spindle throughout metaphase, Colocalizes with Aurora kinase AURKB during cytokinesis with the midbody, Colocalizes with microtubules, Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins, Shuttles between the cytoplasm and the nucleus through the CRM1 export pathway, Colocalizes with EP300 in the nucleus, Translocates to the nucleus and chromatin upon bacterium Listeria monocytogenes infection in interphase cells, SUBCELLULAR LOCATION: Isoform 1: Cytoplasm, Nucleus, Note=Predominantly localized in the cytoplasmic, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, Nucleus, Note=Predominantly localized in the cytoplasmic, SUBCELLULAR LOCATION: Isoform 5: Cytoplasm, Nucleus

Rgd	621481
Target Details	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. This protein is included in class I of the sirtuin family. Two transcript variants result from alternative splicing of this gene.
Uniprot	Q8IXJ6
Database Links	HGNC:10886 OMIM:604480 KEGG:hsa:22933 STRING:9606.ENSP00000249396 UniGene:Hs.466693
Function	NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors
Protein Families	Sirtuin family, Class I subfamily
Tissue Specificity	Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557116	CSB-PA021340KA01HU	100μl	$387.33		Add to Cart

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