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Home / Primary Antibodies / IHC Antibodies

SH2D1B Antibody

SKU : BHA10523036

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA021210LA01HU
Alternative Names	SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2), SH2D1B, EAT2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine procuction dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).
Host	Rabbit
Immunogen	Recombinant Human SH2 domain-containing protein 1B protein (1-77AA)
Isotype	IgG
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine procuction dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).
Species	Homo Sapiens (Human)

Uniprot	O14796
Database Links	HGNC:30416 OMIM:608510 KEGG:hsa:117157 STRING:9606.ENSP00000356906 UniGene:Hs.350581
Function	Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244
Pathway	Natural killer cell mediated cytotoxicity
Research Area	Immunology

Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form	Liquid
Format	Liquid
Purification	>95%, Protein G purified
Purity	>95%,Protein G purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Applications

ELISA, IHC, IF

Description

ELISA ; IHC ; IF, IF ; ELISA ; IHC

Dilution

IHC	1:20-1:200
IF	1:50-1:200

Tested Application

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10523036	CSB-PA021210LA01HU	100ug	$299		Add to Cart
BHA10523036	CSB-PA021210LA01HU	50ug	$166		Add to Cart

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