Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth.Velasco-Miguel S., Oncogene 18:127-137(1999).Peeters H., Hum. Genet. 112:573-580(2003).Mungall A.J., Nature 425:805-811(2003).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human SESN1.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth.
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway
Pathway
p53 signaling pathway
Protein Families
Sestrin family
Tissue Specificity
Widely expressed.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.