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Home / Primary Antibodies / IHC Antibodies

SCN5A Antibody

SKU : BHA10559209

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA280563
Alternative Names	CIN5; HH1; SCN5A; Sodium channel protein; cardiac muscle alpha-subunit
Categories	Primary Antibodies
Clonality	polyclonal
Description	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.Sebastian K.G. Maier, Circulation, Mar 2004; 109: 1421 - 1427. T.R. Cummins, Neurology, Jan 2003; 60: 224 - 229. Christopher A. Ahern, Circ. Res., May 2005; 96: 991 - 998. Jyoti Dhar Malhotra, Circulation, Mar 2001; 103: 1303 - 1310.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human sodium channel.
Involvement In Disease	Progressive familial heart block 1A (PFHB1A); Long QT syndrome 3 (LQT3); Brugada syndrome 1 (BRGDA1); Sick sinus syndrome 1 (SSS1); Familial paroxysmal ventricular fibrillation 1 (VF1); Sudden infant death syndrome (SIDS); Atrial standstill 1 (ATRST1); Cardiomyopathy, dilated 1E (CMD1E); Atrial fibrillation, familial, 10 (ATFB10)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels. Sebastian K.G. Maier, Circulation, Mar 2004; 109: 1421 - 1427. T.R. Cummins, Neurology, Jan 2003; 60: 224 - 229. Christopher A. Ahern, Circ. Res., May 2005; 96: 991 - 998. Jyoti Dhar Malhotra, Circulation, Mar 2001; 103: 1303 - 1310.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total sodium channel protein.
Subcellular Location	Cell membrane, Multi-pass membrane protein, Cytoplasm, perinuclear region

Uniprot	Q14524
Database Links	HGNC:10593 OMIM:108770 KEGG:hsa:6331 STRING:9606.ENSP00000328968 UniGene:Hs.517898
Function	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient
Protein Families	Sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily
Tissue Specificity	Found in jejunal circular smooth muscle cells (at protein level). Expressed in human atrial and ventricular cardiac muscle but not in adult skeletal muscle, brain, myometrium, liver, or spleen. Isoform 4 is expressed in brain.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559209	CSB-PA280563	100ul	$297		Add to Cart

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