DNA polymerase zeta catalytic subunit; DPOLZ; DPOZ; EC 2.7.7.7; POLZ
Categories
Primary Antibodies
Clonality
polyclonal
Description
Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis.Gibbs P.E.M., Proc. Natl. Acad. Sci. U.S.A. 95:6876-6880(1998).Lin W., Mutat. Res. 433:89-98(1999).Morelli C., Cytogenet. Cell Genet. 83:18-20(1998).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human DNA Polymerase ζ.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis.
Gibbs P.E.M., Proc. Natl. Acad. Sci. U.S.A. 95:6876-6880(1998). Lin W., Mutat. Res. 433:89-98(1999). Morelli C., Cytogenet. Cell Genet. 83:18-20(1998).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total DNA Polymerase ζ protein.
Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.
Protein Families
DNA polymerase type-B family
Tissue Specificity
Ubiquitously expressed.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.