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Home / Primary Antibodies / IHC Antibodies

RARB Antibody

SKU : BHA10559771

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA127878
Alternative Names	RAR-beta;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.Reuben Lotan, N. Engl. J. Med., May 1995; 332: 1405 - 1411. Andrew Yen, Mol. Pharmacol., Dec 2004; 66: 1727 - 1737. K Swisshelm, Cell Growth Differ., Feb 1994; 5: 133. F Aoudjit, Cell Growth Differ., May 1995; 6: 515.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human Retinoic Acid Receptor β.
Involvement In Disease	Microphthalmia, syndromic, 12 (MCOPS12)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Reuben Lotan, N. Engl. J. Med., May 1995; 332: 1405 - 1411. Andrew Yen, Mol. Pharmacol., Dec 2004; 66: 1727 - 1737. K Swisshelm, Cell Growth Differ., Feb 1994; 5: 133. F Aoudjit, Cell Growth Differ., May 1995; 6: 515.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Retinoic Acid Receptor β protein.
Subcellular Location	Isoform Beta-1: Nucleus, SUBCELLULAR LOCATION: Isoform Beta-2: Nucleus, SUBCELLULAR LOCATION: Isoform Beta-4: Cytoplasm

Uniprot	P10826
Database Links	HGNC:9865 OMIM:180220 KEGG:hsa:5915 STRING:9606.ENSP00000332296 UniGene:Hs.543218
Function	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
Protein Families	Nuclear hormone receptor family, NR1 subfamily

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559771	CSB-PA127878	100ul	$297		Add to Cart

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