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Home / Primary Antibodies / IHC Antibodies

RAPGEF3 Antibody

SKU : BHA10557366

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA019331KA01HU
Alternative Names	RAPGEF3;CAMP-GEFI; EPAC; EPAC1; HSU79275; MGC21410; bcm910;
Categories	Primary Antibodies
Description	EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation, exocytosis, insulin signaling axon growth and guidance and neurotransmitter release.
Hgnc	16629
Host	Rabbit
Immunogen	Recombinant protein of Human RAPGEF3
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Isotype	IgG
Mgi	2441741
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation, exocytosis, insulin signaling axon growth and guidance and neurotransmitter release.
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Endomembrane system

Rgd	621869
Uniprot	O95398
Database Links	HGNC:16629 OMIM:606057 KEGG:hsa:10411 STRING:9606.ENSP00000373864 UniGene:Hs.8578
Function	Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Pathway	cAMP signaling pathway Leukocyte transendothelial migration Oxidative Phosphorylation Phospholipase D signaling pathway Rap1 signaling pathway
Tissue Specificity	Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557366	CSB-PA019331KA01HU	100μl	$387.33		Add to Cart

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