Rab11-FIP3; EF hands-containing Rab-interacting protein; Eferin;
Antigen
RAB11FIP3
Categories
Primary Antibodies
Clonality
polyclonal
Description
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton.Prekeris R., J. Biol. Chem. 276:38966-38970(2001).Ishikawa K., DNA Res. 5:169-176(1998).Daniels R.J., Hum. Mol. Genet. 10:339-352(2001).
Host
Rabbit
Immunogen
Synthesized peptide derived from C-terminal of Human RAB11FIP3.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton.
Prekeris R., J. Biol. Chem. 276:38966-38970(2001). Ishikawa K., DNA Res. 5:169-176(1998). Daniels R.J., Hum. Mol. Genet. 10:339-352(2001).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total RAB11FIP3 protein.
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track)
Pathway
Endocytosis
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.