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Home / Primary Antibodies / IHC Antibodies

PTPN11 Antibody

SKU : BHA10559772

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA041940
Alternative Names	PTN11; PTP-1D; PTP-2C; PTP2C; PTPN11
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.T Noguchi, Mol. Cell. Biol., Oct 1994; 14: 6674 - 6682. U Dechert, J. Biol. Chem., Feb 1994; 269: 5602 - 5611. Hiroshi Ohnishi, J. Biol. Chem., Oct 1996; 271: 25569. Tetsuya Noguchi, J. Biol. Chem., Nov 1996; 271: 27652.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human SH-PTP2.
Involvement In Disease	LEOPARD syndrome 1 (LPRD1); Noonan syndrome 1 (NS1); Leukemia, juvenile myelomonocytic (JMML); Metachondromatosis (MC)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. T Noguchi, Mol. Cell. Biol., Oct 1994; 14: 6674 - 6682. U Dechert, J. Biol. Chem., Feb 1994; 269: 5602 - 5611. Hiroshi Ohnishi, J. Biol. Chem., Oct 1996; 271: 25569. Tetsuya Noguchi, J. Biol. Chem., Nov 1996; 271: 27652.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total SH-PTP2 protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q06124
Database Links	HGNC:9644 OMIM:151100 KEGG:hsa:5781 STRING:9606.ENSP00000340944 UniGene:Hs.506852
Function	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway
Pathway	Jak-STAT signaling pathway Ras signaling pathway Leukocyte transendothelial migration Natural killer cell mediated cytotoxicity Adipocytokine signaling pathway Phospholipase D signaling pathway Neurotrophin signaling pathway
Protein Families	Protein-tyrosine phosphatase family, Non-receptor class 2 subfamily
Tissue Specificity	Widely expressed, with highest levels in heart, brain, and skeletal muscle.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559772	CSB-PA041940	100ul	$297		Add to Cart

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