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Home / Primary Antibodies / IHC Antibodies

PTCH1 Antibody

SKU : BHA10559765

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA914197
Alternative Names	DROSOPHILA HOMOLOG OF 1; patched homolog (Drosophila);
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.Trudy G. Oliver, Development, May 2005; 132: 2425 - 2439. Florence Brellier, Cancer Res., Apr 2004; 64: 2699 - 2704. Heidi Hahn, J. Biol. Chem., May 1996; 271: 12125. RL Johnson, Development, Dec 1995; 121: 4161.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human Patched.
Involvement In Disease	Basal cell nevus syndrome (BCNS); Basal cell carcinoma (BCC); Holoprosencephaly 7 (HPE7)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. Trudy G. Oliver, Development, May 2005; 132: 2425 - 2439. Florence Brellier, Cancer Res., Apr 2004; 64: 2699 - 2704. Heidi Hahn, J. Biol. Chem., May 1996; 271: 12125. RL Johnson, Development, Dec 1995; 121: 4161.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Patched protein.
Subcellular Location	Membrane, Multi-pass membrane protein

Uniprot	Q13635
Database Links	HGNC:9585 OMIM:109400 KEGG:hsa:5727 STRING:9606.ENSP00000332353 UniGene:Hs.494538
Function	Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
Pathway	cAMP signaling pathway Hedgehog signaling pathway
Protein Families	Patched family
Tissue Specificity	In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559765	CSB-PA914197	100ul	$297		Add to Cart

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