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Home / Primary Antibodies / IHC Antibodies

PRKAA1 (Ab-174/172) Antibody

SKU : BHA10559639

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA913725
Alternative Names	AMPK, AMPKa1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. Hurley RL, et al. (2005) J Biol Chem. Aug 12; 280(32): 29060-29066Woods A, et al. (2003) Curr Biol. Nov 11; 13(22): 2004-2008Nielsen JN, et al. (2003) J Appl Physiol. Feb; 94(2): 631-641Da Silva Xavier G, et al. (2000) Proc Natl Acad Sci U S A. Apr 11; 97(8): 4023-4028.
Host	Rabbit
Immunogen	Peptide sequence around aa. 172~176/170~174 (L-R-T-S-C) derived from Human AMPKa1/AMPKa2.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. Hurley RL, et al. (2005) J Biol Chem. Aug 12; 280(32): 29060-29066 Woods A, et al. (2003) Curr Biol. Nov 11; 13(22): 2004-2008 Nielsen JN, et al. (2003) J Appl Physiol. Feb; 94(2): 631-641 Da Silva Xavier G, et al. (2000) Proc Natl Acad Sci U S A. Apr 11; 97(8): 4023-4028.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total AMPKa1/AMPKa2 protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q13131
Gene Id	5562
Database Links	HGNC:9376 OMIM:602739 KEGG:hsa:5562 STRING:9606.ENSP00000346148 UniGene:Hs.43322
Function	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes
Pathway	mTOR signaling pathway PI3K-Akt signaling pathway Autophagy Adipocytokine signaling pathway AMPK signaling Apelin signaling pathway FoxO signaling pathway Glucagon signaling pathway Insulin signaling pathway
Protein Families	Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Weight	64009 MW

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
IF	1:100-1:200

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:1000,IHC:1:50-1:200,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559639	CSB-PA913725	100ul	$297		Add to Cart

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