DNA polymerase subunit gamma-2; mitochondrial; EC 2.7.7.7; Mitochondrial DNA polymerase accessory subunit; PolG-beta
Antigen
POLG2
Categories
Primary Antibodies
Clonality
polyclonal
Description
Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.Lim S.E., J. Biol. Chem. 274:38197-38203(1999).Johnson A.A., Biochemistry 39:1702-1708(2000).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human POLG2.
Involvement In Disease
Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 4 (PEOA4)
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.
Lim S.E., J. Biol. Chem. 274:38197-38203(1999). Johnson A.A., Biochemistry 39:1702-1708(2000).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total POLG2 protein.
Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.