Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear Wang KK, et al. (1991) Biochem J 279(Pt 2): 537-544.Sekimoto T, et al. (2004) EMBO J 23(9): 1934-1942.Doye V, et al. (1992) Biochem J 287(Pt 2): 549-554.Larsson N, et al. (1999) Mol Cell Biol 19(3): 2242-2250.
Host
Rabbit
Immunogen
Peptide sequence around phosphorylation site of serine 38 (P-L-S(p)-P-P) derived from Human Stathmin 1.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear
Wang KK, et al. (1991) Biochem J 279(Pt 2): 537-544. Sekimoto T, et al. (2004) EMBO J 23(9): 1934-1942. Doye V, et al. (1992) Biochem J 287(Pt 2): 549-554. Larsson N, et al. (1999) Mol Cell Biol 19(3): 2242-2250.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of Stathmin 1 only when phosphorylated at serine 38.
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
Pathway
MAPK signaling pathway
Protein Families
Stathmin family
Tissue Specificity
Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at subs
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.