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Home / Primary Antibodies / IHC Antibodies

Phospho-SMAD2 (S467) Antibody

BHA10542207
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Tel
+1 866.986.9598
Email
[email protected]
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Uniprot Q15796
Database Links

HGNC:6768

OMIM:601366

KEGG:hsa:4087

STRING:9606.ENSP00000262160

UniGene:Hs.12253
Function Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Pathway Hippo signaling pathway TGF-beta signaling pathway Adherens junction Cell cycle Cellular senescence Signaling pathways regulating pluripotency of stem cells Th17 cell differentiation AGE-RAGE signaling pathway in diabetic complications Apelin signaling pathway FoxO signaling pathway Endocytosis
Protein Families Dwarfin/SMAD family
Tissue Specificity Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Format Liquid
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications WB, IHC, ELISA
Description WB ; IHC ; ELISA, WB ; ELISA ; IHC
Dilution

WB1:500-1:2000
IHC1:100-1:300
ELISA1/5000
Tested Application WB,IHC,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000
Datasheet
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
SKU Supplier No. Size Your price Quantity
BHA10542207 CSB-PA000675 100ug $167
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BHA10542207 CSB-PA000675 50ug $100
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