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Home / Primary Antibodies / IHC Antibodies

Phospho-PLD2 (Tyr169) Antibody

SKU : BHA10560486

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA983138
Alternative Names	PLD 2; PLD1C; choline phosphatase 2;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.Steed P.M., FASEB J. 12:1309-1317(1998).Lopez I., J. Biol. Chem. 273:12846-12852(1998).Divecha N., EMBO J. 19:5440-5449(2000).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine 169(E-N-Y(p)-L-N) derived from Human PLD2.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control. Steed P.M., FASEB J. 12:1309-1317(1998). Lopez I., J. Biol. Chem. 273:12846-12852(1998). Divecha N., EMBO J. 19:5440-5449(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of PLD2 only when phosphorylated at tyrosine 169.
Subcellular Location	Membrane, Peripheral membrane protein

Uniprot	O14939
Database Links	HGNC:9068 OMIM:602384 KEGG:hsa:5338 STRING:9606.ENSP00000263088 UniGene:Hs.104519
Function	May have a role in signal-induced cytoskeletal regulation and/or endocytosis.
Pathway	cAMP signaling pathway Ras signaling pathway Fc gamma R-mediated phagocytosis Oxidative Phosphorylation Phospholipase D signaling pathway Sphingolipid signaling pathway Endocytosis Glutamatergic synapse
Protein Families	Phospholipase D family
Tissue Specificity	Ubiquitous.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560486	CSB-PA983138	100ul	$360		Add to Cart

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