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Home / Primary Antibodies / IHC Antibodies

Phospho-NOS3 (Ser1177) Antibody

SKU : BHA10560355

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA279955
Alternative Names	Constitutive NOS; EC-NOS; ECNOS; NOS3; NOSIII
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Fulton, D. et al. (1999) Nature 399, 597-601. Harris, M.B. et al. (2001) J. Biol. Chem. 276, 16587-16591. Thomas, S.R. et al. (2002) J. Biol. Chem. 277, 6017-6024.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine 1177 (T-Q-S(p)-F-S) derived from Human eNOS.
Involvement In Disease	Variation Asp-298 in NOS3 may be associated with susceptibility to coronary spasm.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Fulton, D. et al. (1999) Nature 399, 597-601. Harris, M.B. et al. (2001) J. Biol. Chem. 276, 16587-16591. Thomas, S.R. et al. (2002) J. Biol. Chem. 277, 6017-6024.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of eNOS only when phosphorylated at serine 1177.
Subcellular Location	Cell membrane, Membrane, caveola, Cytoplasm, cytoskeleton, Golgi apparatus

Uniprot	P29474
Database Links	HGNC:7876 OMIM:163729 KEGG:hsa:4846 STRING:9606.ENSP00000297494 UniGene:Hs.647092
Function	Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.; FUNCTION
Pathway	Calcium signaling pathway Estrogen signaling pathway HIF-1 signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Nitric oxide signaling AGE-RAGE signaling pathway in diabetic complications Apelin signaling pathway cGMP-PKG signaling pathway Sphingolipid signaling pathway
Protein Families	NOS family
Tissue Specificity	Platelets, placenta, liver and kidney.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC, IF

Description

ELISA ; IHC ; IF, IF ; ELISA ; IHC

Dilution

IHC	1:50-1:100
IF	1:100-1:200

Tested Application

ELISA,IHC,IF;IHC:1:50-1:100,IF:1:100-1:200

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560355	CSB-PA279955	100ul	$360		Add to Cart

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