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Home / Primary Antibodies / IHC Antibodies

Phospho-MAPT (Thr205) Antibody

SKU : BHA10560339

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA271293
Alternative Names	MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.del C Alonso A, et al. (2004) J Biol Chem; 279(33): 34873-81Li G, Yin H, Kuret J (2004) J Biol Chem; 279(16): 15938-45Giasson BI, et al. (2002) Biochemistry; 41(51): 15376-87Liu F, et al. (2002) FEBS Lett; 530(1-3): 209Taniguchi T, et al. (2001) J Biol Chem; 276(13): 10025-31
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of threonine 205 (P-G-T(p)-P-G) derived from Human Tau.
Involvement In Disease	Frontotemporal dementia (FTD); Pick disease of the brain (PIDB); Progressive supranuclear palsy 1 (PSNP1); Parkinson-dementia syndrome (PARDE)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. del C Alonso A, et al. (2004) J Biol Chem; 279(33): 34873-81 Li G, Yin H, Kuret J (2004) J Biol Chem; 279(16): 15938-45 Giasson BI, et al. (2002) Biochemistry; 41(51): 15376-87 Liu F, et al. (2002) FEBS Lett; 530(1-3): 209 Taniguchi T, et al. (2001) J Biol Chem; 276(13): 10025-31
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Tau only when phosphorylated at threonine 205.
Subcellular Location	Cytoplasm, cytosol, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, cytoskeleton, Cell projection, axon

Uniprot	P10636
Database Links	HGNC:6893 OMIM:157140 KEGG:hsa:4137 STRING:9606.ENSP00000340820 UniGene:Hs.101174
Function	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Pathway	MAPK signaling pathway
Tissue Specificity	Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560339	CSB-PA271293	100ul	$360		Add to Cart

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