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Home / Primary Antibodies / IHC Antibodies

Phospho-MAP3K1 (Thr1402) Antibody

SKU : BHA10560465

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA177236
Alternative Names	M3K1; MAP3K1; MAPKKK1; MEKK1;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.Schmutz J., Nature 431:268-274(2004).Xia Y., Genes Dev. 12:3369-3381(1998).Vinik B.S., Mamm. Genome 6:782-783(1995)
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of threonine 1402(T-G-A(p)-G-F) derived from Human MAP3K1.
Involvement In Disease	46,XY sex reversal 6 (SRXY6)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. Schmutz J., Nature 431:268-274(2004). Xia Y., Genes Dev. 12:3369-3381(1998). Vinik B.S., Mamm. Genome 6:782-783(1995)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of MAP3K1 only when phosphorylated at threonine 1402.

Uniprot	Q13233
Database Links	HGNC:6848 OMIM:600982 KEGG:hsa:4214 STRING:9606.ENSP00000382423 UniGene:Hs.653654
Function	Component of a protein kinase signal transduction cascade
Pathway	MAPK signaling pathway Ubiquitin mediated proteolysis Neurotrophin signaling pathway
Protein Families	Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560465	CSB-PA177236	100ul	$360		Add to Cart

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