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Home / Primary Antibodies / IHC Antibodies

Phospho-ITK (Y512) Antibody

BHA10539284
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
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Uniprot Q08881
Database Links

HGNC:6171

OMIM:186973

KEGG:hsa:3702

STRING:9606.ENSP00000398655

UniGene:Hs.558348
Function Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins
Pathway Chemokine signaling pathway Leukocyte transendothelial migration T cell receptor signaling pathway
Protein Families Protein kinase superfamily, Tyr protein kinase family, TEC subfamily
Tissue Specificity T-cell lines and natural killer cell lines.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Format Liquid
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications WB, IHC, ELISA
Description WB ; IHC ; ELISA, WB ; ELISA ; IHC
Dilution

IHC1:100-1:300
ELISA1/5000
Tested Application WB,IHC,ELISA;IHC:1/100-1/300.ELISA:1/5000
Datasheet
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
SKU Supplier No. Size Your price Quantity
BHA10539284 CSB-PA011277 100ug $167
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BHA10539284 CSB-PA011277 50ug $100
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