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Home / Primary Antibodies / IHC Antibodies

Phospho-ITGB4 (Tyr1510) Antibody

SKU : BHA10560457

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA111732
Alternative Names	GP150; ITB4; CD104 antigen;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.Suzuki S., EMBO J. 9:757-763(1990).Hogervorst F., EMBO J. 9:765-770(1990).Tamura R.N., J. Cell Biol. 111:1593-1604(1990).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine1510(R-D-Y(p)-S-T) derived from Human ITGB4 .
Involvement In Disease	Epidermolysis bullosa letalis, with pyloric atresia (EB-PA); Generalized atrophic benign epidermolysis bullosa (GABEB)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. Suzuki S., EMBO J. 9:757-763(1990). Hogervorst F., EMBO J. 9:765-770(1990). Tamura R.N., J. Cell Biol. 111:1593-1604(1990).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of ITGB4 only when phosphorylated at tyrosine 1510.
Subcellular Location	Cell membrane, Single-pass type I membrane protein, Cell membrane, Lipid-anchor, Cell junction, hemidesmosome

Uniprot	P16144
Database Links	HGNC:6158 OMIM:147557 KEGG:hsa:3691 STRING:9606.ENSP00000200181 UniGene:Hs.632226
Function	Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6
Pathway	PI3K-Akt signaling pathway Focal adhesion Regulation of actin cytoskeleton
Protein Families	Integrin beta chain family
Tissue Specificity	Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560457	CSB-PA111732	100ul	$360		Add to Cart

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