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Home / Primary Antibodies / IHC Antibodies

Phospho-ITGB3 (Tyr773) Antibody

SKU : BHA10560320

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA580088
Alternative Names	CD61 antigen; GP3A; GPIIIa; ITB3; Platelet membrane glycoprotein IIIa
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Integrin a-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin a-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins a-IIb/beta-3 and a-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin a-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin a-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.Chandhoke SK, et al. (2004) J Cell Sci.117 (Pt 8): 1431-1441.Datta A, et al. (2002) J Biol Chem.277 (6): 3943-3949.Law DA, et al. (1996) J Biol Chem.271 (18): 10811-10815.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine 773 (P-L-Y(p)-K-E) derived from Human Integrin b3.
Involvement In Disease	Glanzmann thrombasthenia (GT); Bleeding disorder, platelet-type 16 (BDPLT16)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Integrin a-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin a-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins a-IIb/beta-3 and a-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin a-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin a-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Chandhoke SK, et al. (2004) J Cell Sci.117 (Pt 8): 1431-1441. Datta A, et al. (2002) J Biol Chem.277 (6): 3943-3949. Law DA, et al. (1996) J Biol Chem.271 (18): 10811-10815.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Integrin b3 only when phosphorylated at tyrosine 773.
Subcellular Location	Cell membrane, Single-pass type I membrane protein, Cell projection, lamellipodium membrane, Cell junction, focal adhesion

Uniprot	P05106
Database Links	HGNC:6156 OMIM:173470 KEGG:hsa:3690 STRING:9606.ENSP00000262017 UniGene:Hs.218040
Function	Integrin alpha-V/beta-3 (ITGAV
Pathway	PI3K-Akt signaling pathway Focal adhesion Regulation of actin cytoskeleton Hematopoietic cell lineage Osteoclast differentiation Rap1 signaling pathway
Protein Families	Integrin beta chain family
Tissue Specificity	Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560320	CSB-PA580088	100ul	$360		Add to Cart

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