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Home / Primary Antibodies / IHC Antibodies

Phospho-IRS1 (Ser639) Antibody

SKU : BHA10560384

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA004394
Alternative Names	IRS-1; IRS1;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645Tzatsos A, et al. (2006) Mol Cell Biol; 26(1): 63-76Steppan CM, et al. (2005) Mol Cell Biol; 25(4): 1569-1575Batty IH, et al. (2004) Biochem J; 379(Pt 3): 641-651
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine 639 (P-K-S(p)-V-S) derived from Human IRS-1.
Involvement In Disease	Diabetes mellitus, non-insulin-dependent (NIDDM)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645 Tzatsos A, et al. (2006) Mol Cell Biol; 26(1): 63-76 Steppan CM, et al. (2005) Mol Cell Biol; 25(4): 1569-1575 Batty IH, et al. (2004) Biochem J; 379(Pt 3): 641-651
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of IRS-1 only when phosphorylated at serine 639.

Uniprot	P35568
Database Links	HGNC:6125 OMIM:125853 KEGG:hsa:3667 STRING:9606.ENSP00000304895 UniGene:Hs.471508
Function	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Pathway	mTOR signaling pathway PI3K-Akt signaling pathway Autophagy Adipocytokine signaling pathway AMPK signaling cGMP-PKG signaling pathway FoxO signaling pathway Insulin signaling pathway Neurotrophin signaling pathway

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560384	CSB-PA004394	100ul	$360		Add to Cart

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