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Home / Primary Antibodies / IHC Antibodies

Phospho-IKBKG (Ser376) Antibody

SKU : BHA10560186

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA552608
Alternative Names	FIP3; IKBKG; IKKAP1; IKKG; NF-kappaB
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males. In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation. Li Y., Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047(1999).Jin D.-Y., J. Biomed. Sci. 6:115-120(1999).Rothwarf D.M., Nature 395:297-300(1998).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 376(Y-L-S(p)-S-P) derived from Human IKK-γ.
Involvement In Disease	Ectodermal dysplasia, anhidrotic, with immunodeficiency X-linked (EDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis and lymphedema (OLEDAID); Immunodeficiency, NEMO-related, without anhidrotic ectodermal dysplasia (NEMOID); Immunodeficiency 33 (IMD33); Recurrent isolated invasive pneumococcal disease 2 (IPD2); Incontinentia pigmenti (IP)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males. In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation. Li Y., Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047(1999).Jin D.-Y., J. Biomed. Sci. 6:115-120(1999).Rothwarf D.M., Nature 395:297-300(1998).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of IKK-γ only when phosphorylated at serine 376.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q9Y6K9
Database Links	HGNC:5961 OMIM:300248 KEGG:hsa:8517 STRING:9606.ENSP00000358622 UniGene:Hs.43505
Function	Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
Pathway	Chemokine signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway NF-kappa B signaling pathway TNF signaling pathway Apoptosis Ras signaling pathway B cell receptor signaling pathway IL-17 signaling pathway NOD-like receptor signaling pathway Osteoclast differentiation T cell receptor signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Toll-like receptor signaling pathway Adipocytokine signaling pathway
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:50-1:100

Tested Application

ELISA,IHC;IHC:1:50-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560186	CSB-PA552608	100ul	$360		Add to Cart

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