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Home / Primary Antibodies / IHC Antibodies

Phospho-GRIN1 (Ser890) Antibody

SKU : BHA10560451

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA126380
Alternative Names	GLURZ1; GRIN1; NMD-R1; NMDZ1; NMZ1
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.Guang Bai, J. Biol. Chem., Jan 1998; 273: 1086. Guang Bai, J. Biol. Chem., Mar 1995; 270: 7737. Mai T. Dang, PNAS, Oct 2006; 103: 15254 - 15259.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 890(A-S-S(p)-F-K) derived from Human NMDAR1.
Involvement In Disease	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant (NDHMSD)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes. Guang Bai, J. Biol. Chem., Jan 1998; 273: 1086. Guang Bai, J. Biol. Chem., Mar 1995; 270: 7737. Mai T. Dang, PNAS, Oct 2006; 103: 15254 - 15259.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of NMDAR1 only when phosphorylated at serine 890.
Subcellular Location	Cell membrane, Multi-pass membrane protein, Cell junction, synapse, postsynaptic cell membrane, Cell junction, synapse, postsynaptic cell membrane, postsynaptic density

Uniprot	Q05586
Database Links	HGNC:4584 OMIM:138249 KEGG:hsa:2902 STRING:9606.ENSP00000360608 UniGene:Hs.558334
Function	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+)
Pathway	Calcium signaling pathway cAMP signaling pathway Ras signaling pathway Rap1 signaling pathway Glutamatergic synapse
Protein Families	Glutamate-gated ion channel (TC 1.A.10.1) family, NR1/GRIN1 subfamily

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC, IF

Description

ELISA ; IHC ; IF, IF ; ELISA ; IHC

Dilution

IHC	1:50-1:100
IF	1:100-1:200

Tested Application

ELISA,IHC,IF;IHC:1:50-1:100,IF:1:100-1:200

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560451	CSB-PA126380	100ul	$360		Add to Cart

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