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Home / Primary Antibodies / IHC Antibodies

Phospho-FADD (Ser191) Antibody

SKU : BHA10560488

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA446731
Alternative Names	MORT1 ; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.Sugano S., Nat. Genet. 36:40-45(2004).Farmer A., Submitted (MAY-2003).Venter J.C., Submitted (JUL-2005).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine191(R-S-G(p)-A-M) derived from Human FADD.
Involvement In Disease	Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations (IEHDCM)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. Sugano S., Nat. Genet. 36:40-45(2004). Farmer A., Submitted (MAY-2003). Venter J.C., Submitted (JUL-2005).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of FADD only when phosphorylated at serine 191.

Uniprot	Q13158
Gene Id	8772
Database Links	HGNC:3573 OMIM:602457 KEGG:hsa:8772 STRING:9606.ENSP00000301838 UniGene:Hs.86131
Function	Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Pathway	TNF signaling pathway Apoptosis Necroptosis IL-17 signaling pathway NOD-like receptor signaling pathway Toll-like receptor signaling pathway
Tissue Specificity	Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Weight	23,279 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560488	CSB-PA446731	100ul	$360		Add to Cart

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