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Home / Primary Antibodies / IHC Antibodies

Phospho-ERBB2 (Y1221/Y1222) Antibody

BHA10536351
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
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Uniprot P04626
Database Links

HGNC:3430

OMIM:137800

KEGG:hsa:2064

STRING:9606.ENSP00000269571

UniGene:Hs.446352
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Pathway Calcium signaling pathway ErbB signaling pathway HIF-1 signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway Focal adhesion Adherens junction Excitatory synapse pathway
Protein Families Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
Tissue Specificity Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Format Liquid
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications WB, IHC, IF, ELISA
Description WB ; IHC ; IF ; ELISA, WB ; ELISA ; IHC ; IF
Dilution

WB1:500-1:2000
IHC1:100-1:300
IF1:200-1:1000
ELISA1:40000
Tested Application WB,IHC,IF,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000
Datasheet
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
SKU Supplier No. Size Your price Quantity
BHA10536351 CSB-PA000733 100ug $167
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BHA10536351 CSB-PA000733 50ug $100
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