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Home / Primary Antibodies / IHC Antibodies

Phospho-EIF4EBP1 (Thr70) Antibody

SKU : BHA10560213

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA203570
Alternative Names	4EBP1; P/OKCL.6; P/OKCL.6; PHAS-I;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.Pause A., Nature 371:762-767(1994).Gevaert K., Nat. Biotechnol. 21:566-569(2003).Haghighat A., EMBO J. 14:5701-5709(1995).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of threonine70 (T-K-T(p)-P-P) derived from Human 4E-BP1.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. Pause A., Nature 371:762-767(1994). Gevaert K., Nat. Biotechnol. 21:566-569(2003). Haghighat A., EMBO J. 14:5701-5709(1995).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of 4E-BP1 only when phosphorylated at threonine 70.

Uniprot	Q13541
Database Links	HGNC:3288 OMIM:602223 KEGG:hsa:1978 STRING:9606.ENSP00000340691 UniGene:Hs.411641
Function	Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex
Pathway	ErbB signaling pathway HIF-1 signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway Cellular senescence AMPK signaling Insulin signaling pathway
Protein Families	EIF4E-binding protein family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:50-1:100

Tested Application

ELISA,IHC;IHC:1:50-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560213	CSB-PA203570	100ul	$360		Add to Cart

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