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Home / Primary Antibodies / IHC Antibodies

Phospho-CDC25C (Ser198) Antibody

SKU : BHA10560222

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA152554
Alternative Names	CDC25M1; MPI1B; MPIP3; EC 3.1.3.48;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	cdc25C is highly conserved during evolution and it plays a key role in the regulation of cell division. The encodedprotein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.Sadhu K., Proc. Natl. Acad. Sci. U.S.A. 87:5139-5143(1990).Bureik M., Int. J. Oncol. 17:1251-1258(2000).Wegener S., Eur. J. Cell Biol. 79:810-815(2000).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 198(E-F-S(p)-L-K) derived from Human CDC25C.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	cdc25C is highly conserved during evolution and it plays a key role in the regulation of cell division. The encodedprotein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. Sadhu K., Proc. Natl. Acad. Sci. U.S.A. 87:5139-5143(1990). Bureik M., Int. J. Oncol. 17:1251-1258(2000). Wegener S., Eur. J. Cell Biol. 79:810-815(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of CDC25C only when phosphorylated at serine 198.
Subcellular Location	Nucleus

Uniprot	P30307
Database Links	HGNC:1727 OMIM:157680 KEGG:hsa:995 STRING:9606.ENSP00000321656 UniGene:Hs.656
Function	Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.
Pathway	Cell cycle
Protein Families	MPI phosphatase family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:50-1:100

Tested Application

ELISA,IHC;IHC:1:50-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560222	CSB-PA152554	100ul	$360		Add to Cart

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