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Home / Primary Antibodies / IHC Antibodies

Phospho-CCNB1 (Ser147) Antibody

SKU : BHA10560585

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA059325
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	The protein encoded by Cyclin B1 is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.Norbury, C. and Nurse, P. (1992) Annu. Rev. Biochem. 61, 441-470.Atherton-Fessler, S. et al. (1993) Mol. Cell. Biol. 13, 1675-1685.Galaktionov, K. et al. (1995) Genes Dev. 9, 1046-1058.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 147 (A-F-S(p)-D-V) derived from Human Cyclin B1.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	The protein encoded by Cyclin B1 is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. Norbury, C. and Nurse, P. (1992) Annu. Rev. Biochem. 61, 441-470. Atherton-Fessler, S. et al. (1993) Mol. Cell. Biol. 13, 1675-1685. Galaktionov, K. et al. (1995) Genes Dev. 9, 1046-1058.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Cyclin B1 only when phosphorylated at serine 147.
Subcellular Location	Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Uniprot	P14635
Database Links	HGNC:1579 OMIM:123836 KEGG:hsa:891 STRING:9606.ENSP00000256442 UniGene:Hs.23960
Function	Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Pathway	p53 signaling pathway Cell cycle Cellular senescence FoxO signaling pathway
Protein Families	Cyclin family, Cyclin AB subfamily

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:1000
IHC	1:50-1:100
IF	1:100-1:200

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:1000,IHC:1:50-1:100,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560585	CSB-PA059325	100ul	$360		Add to Cart

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