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Home / Primary Antibodies / IHC Antibodies

Phospho-CCDC88A (Ser1417) Antibody

SKU : BHA10560229

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA550459
Alternative Names	APE; GIV; GRDN; HkRP1; KIAA1212
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	girdin IS a ubiquitously expressed actin binding protein that plays an important role in the formation of stress fibers and lamellipodia. Subsequent to phosphorylation by Akt, Girdin accumulates at the leading edge of migrating cells and appears to be crucial for the integrity of the actin cytoskeleton and for cell migration. Enomoto A., Dev. Cell 9:389-402(2005).Simpson F., Traffic 6:442-458(2005).Hillier L.W., Nature 434:724-731(2005).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 417(L-E-M(p)-A-Q) derived from Human Girdin .
Involvement In Disease	PEHO-like syndrome (PEHOL)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	girdin IS a ubiquitously expressed actin binding protein that plays an important role in the formation of stress fibers and lamellipodia. Subsequent to phosphorylation by Akt, Girdin accumulates at the leading edge of migrating cells and appears to be crucial for the integrity of the actin cytoskeleton and for cell migration. Enomoto A., Dev. Cell 9:389-402(2005). Simpson F., Traffic 6:442-458(2005). Hillier L.W., Nature 434:724-731(2005).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of Girdin only when phosphorylated at serine 1417.
Subcellular Location	Membrane, Cell membrane, Cytoplasm, cytosol, Cytoplasmic vesicle, Cell projection, lamellipodium, Cytoplasm, cytoskeleton, cilium basal body, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole

Uniprot	Q3V6T2
Database Links	HGNC:25523 OMIM:609736 KEGG:hsa:55704 STRING:9606.ENSP00000338728 UniGene:Hs.292925
Function	Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself (By similarity). Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration
Protein Families	CCDC88 family
Tissue Specificity	Expressed ubiquitously.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:50-1:100

Tested Application

ELISA,IHC;IHC:1:50-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560229	CSB-PA550459	100ul	$360		Add to Cart

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