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Home / Primary Antibodies / IHC Antibodies

Phospho-CBX5 (Ser92) Antibody

SKU : BHA10560211

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA796826
Alternative Names	HP1A; HP1 alpha; antigen p25;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing.Saunders W.S., J. Cell Sci. 104:573-582(1993).Ye Q., J. Biol. Chem. 271:14653-14656(1996).Ye Q., J. Biol. Chem. 272:14983-14989(1997).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 92(R-S-S(p)-N-F) derived from Human HP1α .
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing.Saunders W.S., J. Cell Sci. 104:573-582(1993).Ye Q., J. Biol. Chem. 271:14653-14656(1996).Ye Q., J. Biol. Chem. 272:14983-14989(1997).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of HP1α only when phosphorylated at serine 92.
Subcellular Location	Nucleus, Chromosome, Chromosome, centromere

Uniprot	P45973
Database Links	HGNC:1555 OMIM:604478 KEGG:hsa:23468 STRING:9606.ENSP00000209875 UniGene:Hs.349283
Function	Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:50-1:100

Tested Application

ELISA,IHC;IHC:1:50-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560211	CSB-PA796826	100ul	$360		Add to Cart

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