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Home / Primary Antibodies / IHC Antibodies

Phospho-ATF4 (Ser245) Antibody

SKU : BHA10560319

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA599947
Alternative Names	C/ATF; C/EBP-related ATF; CREB2
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	ATF4 encodes a transcription factor that was originally identified as a widely expressed mammalian DNA bindingprotein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.Yang X, et al. (2004). Cell.117(3): 387-398.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine 245 (N-R-S(p)-L-P) derived from Human ATF4.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	ATF4 encodes a transcription factor that was originally identified as a widely expressed mammalian DNA bindingprotein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication. Yang X, et al. (2004). Cell.117(3): 387-398.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of ATF4 only when phosphorylated at serine 245.
Subcellular Location	Cytoplasm, Cell membrane, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Uniprot	P18848
Gene Id	468
Database Links	HGNC:786 OMIM:604064 KEGG:hsa:468 STRING:9606.ENSP00000336790 UniGene:Hs.496487
Function	Transcriptional activator. Binds the cAMP response element (CRE) (consensus
Pathway	Estrogen signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway TNF signaling pathway Apoptosis MAPK Erk pathway Protein processing in endoplasmic reticulum Th17 cell differentiation Thyroid hormone synthesis cGMP-PKG signaling pathway ER Stress pathway Glucagon signaling pathway Neurotrophin signaling pathway
Protein Families	BZIP family
Weight	38,590 Da

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560319	CSB-PA599947	100ul	$360		Add to Cart

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