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Home / Primary Antibodies / IHC Antibodies

Phospho-ADAM17 (T735) Antibody

BHA10541197
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Tel
+1 866.986.9598
Email
[email protected]
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Uniprot P78536
Gene Id 6868
Database Links

HGNC:195

OMIM:603639

KEGG:hsa:6868

STRING:9606.ENSP00000309968

UniGene:Hs.404914
Function Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
Pathway Notch signaling pathway
Tissue Specificity Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Weight 93,021 Da
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Format Liquid
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications WB, IHC, ELISA
Description WB ; IHC ; ELISA, WB ; ELISA ; IHC
Dilution

WB1:500-1:2000
IHC1:100-1:300
ELISA1:20000
Tested Application WB,IHC,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000
Datasheet
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
SKU Supplier No. Size Your price Quantity
BHA10541197 CSB-PA050199 100ug $167
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BHA10541197 CSB-PA050199 50ug $100
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