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Home / Primary Antibodies / IHC Antibodies

NFKBIE (Ab-22) Antibody

SKU : BHA10559050

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA148874
Alternative Names	I-kappa-B-epsilon
Categories	Primary Antibodies
Clonality	polyclonal
Description	Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.Shirane M, et al. (1999) J Biol Chem; 274(40): 28169-74Karin, M. and Ben-Neriah, Y. (2000) Annu. Rev. Immunol. ;18, 621-663.Chen, Z.J. et al. (1996) Cell; 84, 853-862.Brown, K. et al. (1995) Science; 267, 1485-1488.
Host	Rabbit
Immunogen	Peptide sequence around aa. 20~24 (I-E-S-L-R) derived from Human IkB-e.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Shirane M, et al. (1999) J Biol Chem; 274(40): 28169-74 Karin, M. and Ben-Neriah, Y. (2000) Annu. Rev. Immunol. ;18, 621-663. Chen, Z.J. et al. (1996) Cell; 84, 853-862. Brown, K. et al. (1995) Science; 267, 1485-1488.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total IkB-e protein.
Subcellular Location	Cytoplasm

Uniprot	O00221
Database Links	HGNC:7799 OMIM:604548 KEGG:hsa:4794 STRING:9606.ENSP00000275015 UniGene:Hs.458276
Function	Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.
Pathway	B cell receptor signaling pathway T cell receptor signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Adipocytokine signaling pathway Neurotrophin signaling pathway
Protein Families	NF-kappa-B inhibitor family
Tissue Specificity	Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559050	CSB-PA148874	100ul	$297		Add to Cart

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