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Home / Primary Antibodies / IHC Antibodies

NFE2L2 Antibody

SKU : BHA10559759

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA828758
Alternative Names	HEBP1; NF-E2 related factor 2; NF2L2; NFE2-related factor 2; NFE2L2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.Rajesh K. Thimmulappa, J. Clin. Invest., Apr 2006; 116: 984 - 995. Sara B. Cullinan, Mol. Cell. Biol., Oct 2003; 23: 7198 - 7209. Tirumalai Rangasamy, J. Exp. Med., Jul 2005; 202: 47 - 59. Wenge Li, J. Biol. Chem., Aug 2005; 280: 28430 - 28438.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human NRF2.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. Rajesh K. Thimmulappa, J. Clin. Invest., Apr 2006; 116: 984 - 995. Sara B. Cullinan, Mol. Cell. Biol., Oct 2003; 23: 7198 - 7209. Tirumalai Rangasamy, J. Exp. Med., Jul 2005; 202: 47 - 59. Wenge Li, J. Biol. Chem., Aug 2005; 280: 28430 - 28438.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total NRF2 protein.
Subcellular Location	Cytoplasm, cytosol, Nucleus

Uniprot	Q16236
Database Links	HGNC:7782 OMIM:600492 KEGG:hsa:4780 STRING:9606.ENSP00000380252 UniGene:Hs.744006
Function	Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Pathway	Protein processing in endoplasmic reticulum Cell ageing and metabolism
Protein Families	BZIP family, CNC subfamily
Tissue Specificity	Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559759	CSB-PA828758	100ul	$297		Add to Cart

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