MIB1 Antibody

Mfr.No.	CSB-PA13289A0Rb
Alternative Names	E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2), MIB1, DIP1 KIAA1323 ZZANK2
Categories	Primary Antibodies
Clonality	polyclonal
Host	Rabbit
Immunogen	Recombinant Human E3 ubiquitin-protein ligase MIB1 protein (5-332AA)
Involvement In Disease	Left ventricular non-compaction 7 (LVNC7)
Isotype	IgG
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Species	Homo Sapiens (Human)
Subcellular Location	Cytoplasm, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite, Cell membrane

Uniprot	Q86YT6
Database Links	HGNC:21086 OMIM:608677 KEGG:hsa:57534 STRING:9606.ENSP00000261537 UniGene:Hs.140903
Function	E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
Research Area	Stem Cells
Tissue Specificity	Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined.

Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form	Liquid
Format	Liquid
Purification	>95%, Protein G purified
Purity	>95%,Protein G purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

Tested Application

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10508713	CSB-PA13289A0Rb	100ug	$299		Add to Cart
BHA10508713	CSB-PA13289A0Rb	50ug	$166		Add to Cart